- Title
- Physical and psychological predictors of quality of life in Chinese colorectal cancer patients during chemotherapy
- Creator
- Zhang, Meifen; Peng, Lifen; Liu, Weiyan; Wen, Yongshan; Wu, Xiaodan; Zheng, Meichun; Zhu, Yaping; Liu, Qianwen; Chan, Sally
- Relation
- Cancer Nursing Vol. 38, Issue 4, p. 312-321
- Publisher Link
- http://dx.doi.org/10.1097/NCC.0000000000000190
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2015
- Description
- Background: Maintaining quality of life (QOL) during chemotherapy is a critical aspect of cancer treatment. Instruments have been developed to assess symptom distress, self-efficacy, anxiety, depression, and other factors impacting QOL during cancer treatment, but Chinese versions have become available only recently. Objective: The aim of this study was to identify factors predictive of QOL during chemotherapy in Chinese colorectal cancer (CRC) patients. Methods: Patients completed Chinese versions of the Hospital Anxiety and Depression Scale, MD Anderson Symptom Inventory (a measure of symptom distress), Stanford Inventory of Cancer Patient Adjustment (a measure of self-efficacy), and Functional Assessment of Cancer Treatment-General (a measure of QOL) before and after 3 and 6 months of chemotherapy. Results: Of 152 consecutive CRC patients (men/women, 98/54; mean age, 53.3 ± 11.3 years, 25-75 years; stage II/III, 59/93), 121 completed all questionnaires (79.6%). Self-efficacy dimensions "communication," "activity management," "personal management," and "affective management" improved progressively over 6 months (all P <.05). Fatigue, nausea, lack of appetite, disturbed sleep, and vomiting peaked at 3 months and declined thereafter (P <.05). Patients who are younger than 60 years, are male, and with stage II CRC exhibited higher 3-and 6-month QOL scores (all P <.05). Multiple regression identified self-efficacy, anxiety, and symptom distress as independent predictors of QOL at 6 months. Conclusions: Enhanced self-efficacy, reduced symptom distress, and lower general anxiety would improve QOL during chemotherapy for CRC patients. Implications for Practice: These instruments can help identify CRC patients at risk of low QOL for additional psychotherapy or specific treatment modifications.
- Subject
- anxiety; Chinese patient; colorectal cancer; depression; quality of life; self-efficacy; symptom distress
- Identifier
- http://hdl.handle.net/1959.13/1331979
- Identifier
- uon:26751
- Identifier
- ISSN:0162-220X
- Language
- eng
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