- Title
- Efficacy of the omega-3 index in predicting non-alcoholic fatty liver disease in overweight and obese adults: a pilot study
- Creator
- Parker, Helen M.; O'Connor, Helen T.; Keating, Shelley E.; Cohn, Jeffrey S.; Garg, Manohar L.; Caterson, Ian D.; George, Jacob; Johnson, Nathan A.
- Relation
- NHMRC.1053206 & NHMRC. 1049857
- Relation
- British Journal of Nutrition Vol. 114, Issue 5, p. 780-787
- Publisher Link
- http://dx.doi.org/10.1017/S0007114515002305
- Publisher
- Cambridge University Press
- Resource Type
- journal article
- Date
- 2015
- Description
- Non-alcoholic fatty liver disease (NAFLD) is an independent predictor of CVD in otherwise healthy individuals. Low n-3 PUFA intake has been associated with the presence of NAFLD; however, the relationship between a biomarker of n-3 status - the Omega-3 Index - and liver fat is yet to be elucidated. A total of eighty overweight adults (fifty-six men) completed the anthropometric and biochemical measurements, including the Omega-3 Index, and underwent proton magnetic resonance spectroscopy assessment of liver fat. Bivariate correlations and multiple regression analyses were performed with reference to prediction of liver fat percentage. The mean Omega-3 Index was high in both NAFLD (intrahepatic lipid concentration≥5·5 %) and non-NAFLD groups. The Omega-3 Index, BMI, waist circumference, glucose, insulin, TAG, high-sensitive C-reactive protein (hsCRP) and alanine aminotransferase (ALT) were positively correlated, and HDL and erythrocyte n-6:n-3 ratio negatively correlated with liver fat concentration. Regression analysis found that simple anthropometric and demographic variables (waist, age) accounted for 31 % of the variance in liver fat and the addition of traditional cardiometabolic blood markers (TAG, HDL, hsCRP and ALT) increased the predictive power to 43 %. The addition of the novel erythrocyte fatty acid variable (Omega-3 Index) to the model only accounted for a further 3 % of the variance (P=0·049). In conclusion, the Omega-3 Index was associated with liver fat concentration but did not improve the overall capacity of demographic, anthropometric and blood markers to predict NAFLD.
- Subject
- non-alcoholic fatty liver; n-3 PUFA; omega-3 index; biomarkers
- Identifier
- http://hdl.handle.net/1959.13/1331383
- Identifier
- uon:26621
- Identifier
- ISSN:0007-1145
- Language
- eng
- Reviewed
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