- Title
- The role of infection and inflammation in stillbirths: parallels with SIDS?
- Creator
- Blackwell, Caroline
- Relation
- Frontiers in Immunology Vol. 6
- Publisher Link
- http://dx.doi.org/10.3389/fimmu.2015.00248
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2015
- Description
- It has been suggested that stillbirths are part of the spectrum of infant deaths that includes sudden infant death syndrome (SIDS). This paper examines the hypothesis that risk factors associated with stillbirths might contribute to dysregulation of inflammatory responses to infections that could trigger the physiological responses leading to fetal loss. These include genetic factors (ethnic group, sex), environmental (infection, cigarette smoke, obesity), and developmental (testosterone levels) factors. Interactions between the genetic, environmental, and developmental risk factors are also considered, e.g., the excess of male stillborn infants in relation to the effects of testosterone levels during development on pro-inflammatory responses. In contrast to SIDS, inflammatory responses of both mother and fetus need to be considered. Approaches for examining the hypothesis are proposed.
- Subject
- stillbirth; Sudden Infant Death Syndrome (SIDS); inflammation; infection; cigarette cmoke; ethnicity; obesity; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1330361
- Identifier
- uon:26369
- Identifier
- ISSN:1664-3224
- Rights
- Copyright ©2015 Blackwell. This is an open-access article distributed under the terms of the Creative Commons Attribution License(CCBY). The use,distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
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