Gene expression profile changes in Eisenia fetida chronically exposed to PFOA

Title: Gene expression profile changes in Eisenia fetida chronically exposed to PFOA
Creator: Mayilswami, Srinithi; Krishnan, Kannan; Megharaj, Mallavarapu; Naidu, Ravi
Relation: Ecotoxicology Vol. 25, Issue 4, p. 759-769
Publisher Link: http://dx.doi.org/10.1007/s10646-016-1634-x
Publisher: Springer
Resource Type: journal article
Date: 2016
Description: Eisenia fetida is a terrestrial organism, which can be used to diagnose sub-lethal concentrations of PFOA by using molecular biomarkers. In order to identify potential molecular biomarkers, we have exposed E. fetida to 10 mg/kg of PFOA in soil for 8 months. The mRNA isolation, sequencing, transcriptome assembly followed by differential gene expression studies have revealed that genes that are involved in apoptotic process, reproduction, calcium signalling, neuronal development and lipid metabolism are predominantly affected. Highly specific genes that are altered by PFOA can be further validated and used as biomarker to detect sub-lethal concentrations of PFOA in the soil.
Subject: <i>Eisenia fetida</i>; perfluorooctanoic acid (PFOA); transcriptome assembly; differential gene expression; toxicogenomics
Identifier: http://hdl.handle.net/1959.13/1322869
Identifier: uon:24675
Identifier: ISSN:0963-9292
Language: eng
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