- Title
- Skin sympathetic nerve activity is modulated during slow sinusoidal linear displacements in supine humans
- Creator
- Bolton, Philip S.; Hammam, Elie; Kwok, Kenny; Macefield, Vaughan G.
- Relation
- ARC.DP1096179
- Relation
- Frontiers in Neuroscience Vol. 10
- Publisher Link
- http://dx.doi.org/10.3389/fnins.2016.00039
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2016
- Description
- Low-frequency sinusoidal linear acceleration (0.08 Hz, ±4 mG) modulates skin sympathetic nerve activity (SSNA) in seated subjects (head vertical), suggesting that activation of the utricle in the peripheral vestibular labyrinth modulates SSNA. The aim of the current study was to determine whether SSNA is also modulated by input from the saccule. Tungsten microelectrodes were inserted into the common peroneal nerve to record oligounitary SSNA in 8 subjects laying supine on a motorized platform with the head aligned with the longitudinal axis of the body. Slow sinusoidal (0.08 Hz, 100 cycles) linear acceleration-decelerations (peak ±4 mG) were applied rostrocaudally to predominately activate the saccules, or mediolaterally to predominately activate the utricles. Cross-correlation histograms were constructed between the negative-going sympathetic spikes and the positive peaks of the sinusoidal stimuli. Sinusoidal linear acceleration along the rostrocaudal axis or mediolateral axis both resulted in sinusoidal modulation of SSNA (Median, IQR 27.0, 22-33% and 24.8, 17-39%, respectively). This suggests that both otolith organs act on sympathetic outflow to skin and muscle in a similar manner during supine displacements.
- Subject
- SSNA; sympathetic; utricle; saccule; vestibulosympathetic reflexes
- Identifier
- http://hdl.handle.net/1959.13/1322847
- Identifier
- uon:24670
- Identifier
- ISSN:1662-4548
- Rights
- Copyright © 2016 Bolton, Hammam, Kwok and Macefield. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
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