- Title
- A benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard
- Creator
- Cereda, Carlo W.; Christensen, Søren; Parsons, Mark W.; Lansberg, Maarten G.; Campbell, Bruce C. V.; Mishra, Nishant K.; Mlynash, Michael; Levi, Christopher; Straka, Matus; Wintermark, Max; Bammer, Roland; Albers, Gregory W.
- Relation
- NHMRC.1013719
- Relation
- Journal of Cerebral Blood Flow and Metabolism Vol. 36, Issue 10, p. 1780-1789
- Publisher Link
- http://dx.doi.org/10.1177/0271678X15610586
- Publisher
- Sage
- Resource Type
- journal article
- Date
- 2016
- Description
- Differences in research methodology have hampered the optimization of Computer Tomography Perfusion (CTP) for identification of the ischemic core. We aim to optimize CTP core identification using a novel benchmarking tool. The benchmarking tool consists of an imaging library and a statistical analysis algorithm to evaluate the performance of CTP. The tool was used to optimize and evaluate an in-house developed CTP-software algorithm. Imaging data of 103 acute stroke patients were included in the benchmarking tool. Median time from stroke onset to CT was 185 min (IQR 180-238), and the median time between completion of CT and start of MRI was 36 min (IQR 25-79). Volumetric accuracy of the CTP-ROIs was optimal at an rCBF threshold of <38%; at this threshold, the mean difference was 0.3 ml (SD 19.8 ml), the mean absolute difference was 14.3 (SD 13.7) ml, and CTP was 67% sensitive and 87% specific for identification of DWI positive tissue voxels. The benchmarking tool can play an important role in optimizing CTP software as it provides investigators with a novel method to directly compare the performance of alternative CTP software packages.
- Subject
- cerebrovascular disease; brain imaging; brain ischemia; cerebral blood flow measurement; diffusion weighted MRI
- Identifier
- http://hdl.handle.net/1959.13/1321249
- Identifier
- uon:24301
- Identifier
- ISSN:0271-678X
- Language
- eng
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