- Title
- Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014
- Creator
- Cheng, Allen C.; Kotsimbos, Tom; Bowler, Simon; Senenayake, Sanjaya; Holmes, Mark; Irving, Louis; Brown, Simon G. A.; Waterer, Grant; Dwyer, Dominic E.; Macartney, Kristine; Blyth, Christopher; Kelly, Paul M.; Wark, Peter; Hunter, Cameron; Hewagama, Saliya; Friedman, N. Deborah; Korman, Tony M.; Simpson, Graham; Upham, John W.
- Relation
- Vaccine Vol. 33, Issue 51, p. 7352-7356
- Publisher Link
- http://dx.doi.org/10.1016/j.vaccine.2015.10.016
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2015
- Description
- We provide estimates of the influenza vaccine protection against hospitalisation with laboratory-confirmed influenza in the 2014 Australian season where the A/H1N1/pdm09 strain predominated. This was performed using a case-test negative study design as part of a national sentinel surveillance system in Australia. Vaccine effectiveness was estimated as (1-OR) x 100% where the odds ratio of vaccination in cases vs test negative participants was estimated from a conditional logistic regression. Between April and November, 1692 adult patients were admitted with laboratory-confirmed influenza. Vaccine effectiveness was estimated from 1283 patients with influenza and 1116 test negative patients where vaccination status was ascertained. Vaccination was associated with a reduction in the risk of hospitalisation with influenza of 51.5% (95% CI: 41.6%, 59.7%) in all patients, and a reduction of 50.7% (95% CI: 40.1%, 59.3%) in the target population for vaccination. We estimate that the influenza vaccine was moderately protective against hospitalisation with laboratory-confirmed influenza during the 2014 influenza season in Australia.
- Subject
- influenza vaccination; test negative design; vaccine effectiveness; hospitalisation
- Identifier
- http://hdl.handle.net/1959.13/1317127
- Identifier
- uon:23340
- Identifier
- ISSN:0264-410X
- Language
- eng
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