A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

de Vries, P. S.; Chasman, D. I.; Hottenga, J. J.; Trompet, S; Müller-Nurasyid, M.; Zhao, J. H.; Brody, J. A.; Kleber, M. E.; Guo, X.; Wang, J. J.; Auer, P. L.; Attia, John R.; Sabater-Lleal, M.; Yanek, L. R.; Ahluwalia, T. S.; Lahti, J.; Venturini, C.; Tanaka, T.; Bielak, L. F.; Joshi, P. K.; Rocanin-Arjo, A.; Kolcic, I.; Navarro, P.; Chen, M. H.; Rose, L. M.; Oldmeadow, Christopher; Riess, H.; Mazur, J.; Basu, S.; Goel, A.; Yang, Q.; Ghanbari, M.; Gonneke, Willemsen; Rumley, A.; Huffman, J. E.; Fiorillo, E.; de Craen, A. J. M.; Grotevendt, A.; Scott, R.; Taylor, K. D.; Delgado, G. E.; Yao, J.; Kifley, A.; Kooperberg, C.; Qayyum, R.; Steri, M.; Lopez, L.; Berentzen, T. L.; Räikkönen, K.; Mangino, M.; Bandinelli, S.; Peyser, P. A.; Wild, S.; Trégouët, D. A.; Wright, A. F.; Marten, J.; Tang, W.; Zemunik, T.; Morrison, A. C.; Sennblad, B.; Tofler, G.; de Maat, M. P. M.; De Geus, E. J. C.; Lowe, G. D.; Zoledziewska, M.; Sattar, N.; Binder, H.; Teumer, A.; Völker, U.; Waldenberger, M.; Khaw, K. T.; Scott, Rodney J.; Marioni, R. E.; Grossmann, V.

Title: A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Creator: de Vries, P. S.; Chasman, D. I.; Hottenga, J. J.; Trompet, S; Müller-Nurasyid, M.; Zhao, J. H.; Brody, J. A.; Kleber, M. E.; Guo, X.; Wang, J. J.; Auer, P. L.; Attia, John R.; Sabater-Lleal, M.; Yanek, L. R.; Ahluwalia, T. S.; Lahti, J.; Venturini, C.; Tanaka, T.; Bielak, L. F.; Joshi, P. K.; Rocanin-Arjo, A.; Kolcic, I.; Navarro, P.; Chen, M. H.; Rose, L. M.; Oldmeadow, Christopher; Riess, H.; Mazur, J.; Basu, S.; Goel, A.; Yang, Q.; Ghanbari, M.; Gonneke, Willemsen; Rumley, A.; Huffman, J. E.; Fiorillo, E.; de Craen, A. J. M.; Grotevendt, A.; Scott, R.; Taylor, K. D.; Delgado, G. E.; Yao, J.; Kifley, A.; Kooperberg, C.; Qayyum, R.; Steri, M.; Lopez, L.; Berentzen, T. L.; Räikkönen, K.; Mangino, M.; Bandinelli, S.; Peyser, P. A.; Wild, S.; Trégouët, D. A.; Wright, A. F.; Marten, J.; Tang, W.; Zemunik, T.; Morrison, A. C.; Sennblad, B.; Tofler, G.; de Maat, M. P. M.; De Geus, E. J. C.; Lowe, G. D.; Zoledziewska, M.; Sattar, N.; Binder, H.; Teumer, A.; Völker, U.; Waldenberger, M.; Khaw, K. T.; Scott, Rodney J.; Marioni, R. E.; Grossmann, V.
Relation: Human Molecular Genetics Vol. 25, Issue 2, p. 358-370
Publisher Link: http://dx.doi.org/10.1093/hmg/ddv454
Publisher: Oxford University Press
Resource Type: journal article
Date: 2016
Description: Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels.We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ~120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indelswere examined.We identified 41 genome-wide significant fibrinogen loci; of which, 18were newly identified. Therewere no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
Subject: genome-wide association studies; fibrinogen concentration; http://dx.doi.org/1000 Genomes imputation; X-chromosome
Identifier: http://hdl.handle.net/1959.13/1315939
Identifier: uon:23033
Identifier: ISSN:0964-6906
Language: eng
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