- Title
- Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats
- Creator
- Dias, Cintia B.; Wood, Lisa G.; Phang, Melinda; Garg, Manohar L.
- Relation
- Metabolism: Clinical and Experimental Vol. 64, Issue 12, p. 1658-1666
- Publisher Link
- http://dx.doi.org/10.1016/j.metabol.2015.08.012
- Publisher
- W.B. Saunders
- Resource Type
- journal article
- Date
- 2015
- Description
- Objective: Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied. Method: In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n = 26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8. grams of LCn-3PUFA (300. mg eicosapentaenoic acid, 20:5n-3 and 1500. mg docosahexaenoic acid, 22:6n-3). Results: Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6. hour study period was similar in both the saturated and the n-6 fat groups. Conclusion: These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects.Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853.
- Subject
- postprandial effects; saturated fatty acids; n-6 polyunsaturated fatty acids; n-3 polyunsaturated fatty acids; plasma fatty acids
- Identifier
- http://hdl.handle.net/1959.13/1315061
- Identifier
- uon:22886
- Identifier
- ISSN:0026-0495
- Language
- eng
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