Biomarker of early glomerular injury in pre-eclampsia

Title: Biomarker of early glomerular injury in pre-eclampsia
Creator: Kandasamy, Yogavijayan; Watson, David; Rudd, Donna
Relation: Hypertension in Pregnancy Vol. 34, Issue 4, p. 391-399
Publisher Link: http://dx.doi.org/10.3109/10641955.2015.1065883
Publisher: Taylor & Francis
Resource Type: journal article
Date: 2015
Description: Objectives: Nephrin is an integral part of podocytes that together with endothelial cells and the basement form the glomerular filtration barrier. Placental ischemia triggers a cascade of events that ultimately result in endothelial malfunction, hypertension, podocytopathy and fetal compromise. Methods: We review the literature to determine if urine nephrin measurements could serve as a useful biomarker to detect early podocyte injury in pre-eclampsia. Results: Our search identifies eight studies published to date. The findings of these studies demonstrate that urine nephrin excretion plays a critical role in the pathogenesis of proteinuria during pre-eclampsia and that this is a good indicator of glomerular injury. Conclusion: There is thus an urgent need for a large multi-centre clinical study using standardized recruitment criteria to determine the full potential of this biomarker in clinical practice.
Subject: nephrin; pre-eclampsia; podocytopathy; glomerular injury; hypertension
Identifier: http://hdl.handle.net/1959.13/1315028
Identifier: uon:22880
Identifier: ISSN:1064-1955
Language: eng
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