- Title
- Effects of fetal sex on expression of the (pro)renin receptor and genes influenced by its interaction with prorenin in human amnion
- Creator
- Pringle, Kirsty G.; Conquest, Alison; Mitchell, Carolyn; Zakar, Tamas; Lumbers, Eugenie R.
- Relation
- NHMRC.514706
- Relation
- Reproductive Sciences Vol. 22, Issue 6, p. 750-757
- Publisher Link
- http://dx.doi.org/10.1177/1933719114561555
- Publisher
- Sage
- Resource Type
- journal article
- Date
- 2015
- Description
- Males are more likely to be born preterm than females. The causes are unknown, but it is suggested that intrauterine tissues regulate fetal growth and survival in a sex-specific manner. We postulated that prorenin binding to its prorenin/renin receptor receptor (ATP6AP2) would act in a fetal sex-specific manner in human amnion to regulate the expression of promyelocytic zinc finger, a negative regulator of ATP6AP2 expression as well as 2 pathways that might influence the onset of labor, namely transforming growth factor ß1 (TGFB1) and prostaglandin endoperoxide synthase 2 (PTGS2). Our findings demonstrate that there are strong interactions between prorenin, ATP6AP2, and TGFB1 and that this system has a greater capacity in female amnion to stimulate profibrotic pathways, thus maintaining the integrity of the fetal membranes. In contrast, glucocorticoids or other factors independent of the prorenin/prorenin receptor pathway may be important regulators of PTGS2 in human pregnancy.
- Subject
- amnion; prorenin; prorenin receptor; transforming growth factor; prostaglandin endoperoxide synthase 2
- Identifier
- http://hdl.handle.net/1959.13/1309249
- Identifier
- uon:21815
- Identifier
- ISSN:1933-7191
- Language
- eng
- Full Text
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