- Title
- Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma
- Creator
- Wood, L. G.; Shivappa, N.; Berthon, B. S.; Gibson, P. G.; Hebert, J. R.
- Relation
- Clinical and Experimental Allergy Vol. 45, Issue 1, p. 177-183
- Publisher Link
- http://dx.doi.org/10.1111/cea.12323
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2015
- Description
- Background: Asthma prevalence has increased in recent years, and evidence suggests that diet may be a contributing factor. Increased use of processed foods has led to a decrease in diet quality, which may be creating a pro-inflammatory environment, thereby leading to the development and/or progression of various chronic inflammatory diseases and conditions. Recently, the dietary inflammatory index (DII) has been developed and validated to assess the inflammatory potential of individual diets. Objective: This study aimed to examine the DII in subjects with asthma compared to healthy controls and to relate the DII to asthma risk, lung function and systemic inflammation. Methods: Subjects with asthma (n = 99) and healthy controls (n = 61) were recruited. Blood was collected and spirometry was performed. The DII was calculated from food frequency questionnaires administered to study subjects. Results: The mean DII score for the asthmatics was higher than the mean DII score for healthy controls (- 1.40 vs. - 1.86, P = 0.04), indicating that their diets were more pro-inflammatory. For every 1 unit increase in DII score, the odds of having asthma increased by 70% (OR: 1.70, 95% CI: 1.03, 2.14; P = 0.040). FEV₁ was significantly associated with DII score (ß = - 3.44, 95% CI: - 6.50, - 0.39; P = 0.020), indicating that for every 1 unit increase in DII score, FEV₁ decreased by 3.44 times. Furthermore, plasma IL-6 concentrations were positively associated with DII score (ß = 0.13, 95% CI: 0.05, 0.21; P = 0.002). Conclusion and Clinical Relevance: As assessed using the DII score, the usual diet consumed by asthmatics in this study was pro-inflammatory relative to the diet consumed by the healthy controls. The DII score was associated with increased systemic inflammation and lower lung function. Hence, consumption of pro-inflammatory foods may contribute to worse asthma status, and targeting an improvement in DII in asthmatics, as an indicator of suitable dietary intake, might be a useful strategy for improving clinical outcomes in the disease.
- Subject
- asthma; diet; inflammation
- Identifier
- http://hdl.handle.net/1959.13/1306772
- Identifier
- uon:21250
- Identifier
- ISSN:0954-7894
- Rights
- This is the peer reviewed version of the following article: Wood, L. G.; Shivappa, N.; Berthon, B. S.; Gibson, P. G.; Hebert, J. R. “Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma”, Clinical and Experimental Allergy Vol. 45, Issue 1, p. 177-183 (2015) which has been published in final form at http://dx.doi.org/10.1111/cea.12323. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
- Language
- eng
- Full Text
- Reviewed
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