- Title
- Androgen deprivation therapy for prostate cancer does not increase cardiovascular mortality in the long term
- Creator
- Wilcox, Chantelle; Kautto, Allison; Steigler, Allison; Denham, James W.
- Relation
- Oncology: International Journal of Cancer Research and Treatment Vol. 82, Issue 1, p. 56-58
- Publisher Link
- http://dx.doi.org/10.1159/000334999
- Publisher
- S. Karger AG
- Resource Type
- journal article
- Date
- 2012
- Description
- Objective: To determine if 6 months of neo-adjuvant androgen deprivation is associated with the long-term risk of cardiac mortality. Methods: In the TROG 96.01 trial, 802 men with locally advanced prostate cancer were randomized to radiotherapy either alone or with 3 or 6 months of neo-adjuvant androgen deprivation therapy (NADT). Competing risk methodology was used to derive the cumulative incidence of fatal cardiac events. Results: At 10 years, the cumulative incidence of fatal cardiac events for the radiation therapy alone arm was 7.54% compared to a nonstatistically significant decreased incidence of 6.44% in the 6-month NADT arm (p = 0.65). Men aged over 65 years were not at an increased risk. Additional androgen deprivation therapy given as secondary treatment at tumor progression did not confer an increased risk. Conclusion: These data suggest that fatal cardiac events are not more common in men receiving up to 6 months of NADT.
- Subject
- androgen deprivation therapy; myocardial infarction; prostate cancer
- Identifier
- http://hdl.handle.net/1959.13/1303876
- Identifier
- uon:20745
- Identifier
- ISSN:0030-2414
- Language
- eng
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