Sub-optimal switching with dwell time constraints for control of viral mutation

Title: Sub-optimal switching with dwell time constraints for control of viral mutation
Creator: Hernandez-Vargas, Esteban A.; Colaneri, Patrizio; Middleton, Richard H.
Relation: IEEE 51st Annual Conference on Decision and Control (CDC 2012). Proceedings of the IEEE 51st Annual Conference on Decision and Control (Maui, HI 10-13 December, 2012) p. 4906-4911
Publisher Link: http://dx.doi.org/10.1109/CDC.2012.6426559
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Resource Type: conference paper
Date: 2012
Description: Regulation of mutant viri is important in many disease including HIV infection. Under current multi-drug Anti-Retroviral Therapies for HIV treatment, resistant mutations and failure to regulate viral load is typically observed after approximately 6 years. When this occurs, the current therapy must be abandoned and a new therapy initiated. An alternate approach is to treat this as a switching control problem, wherein therapy may be alternated well before virological failure is observed. In this paper we extend previous work on suboptimal control of a simplified model of HIV infection with mutations. The particular extension here is to include a `dwell time' constraint on the switching actions, that is, impose a strict minimum time between altering therapy.
Subject: HIV; immune systems; linear systems
Identifier: http://hdl.handle.net/1959.13/1303824
Identifier: uon:20727
Language: eng
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