- Title
- Novel 3-substituted ocotillol-type triterpenoid derivatives as antibacterial candidates
- Creator
- Bi, Yi; Ma, Cong; Zhang, Hengyuan; Zhou, Zhiwen; Yang, Jian; Zhang, Zhenlei; Meng, Qingguo; Lewis, Peter J.; Xu, Jinyi
- Relation
- NHMRC.APP1008014 http://purl.org/au-research/grants/nhmrc/1008014
- Relation
- Chemical Biology and Drug Design Vol. 84, Issue 4, p. 489-496
- Publisher Link
- http://dx.doi.org/10.1111/cbdd.12337
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2014
- Description
- Plant-derived triterpenoid saponins are involved in the plant defense system by targeting bacterial membranes. A series of ocotillol-type triterpenoid derivatives were synthesized starting from PPD, one of the main components of Panax ginseng and their antibacterial activity against several representative bacteria were evaluated. Compounds 5 and 11 exhibited excellent antibacterial activity with MIC values of 1 μg/mL against Staphylococcus aureus and 8 μg/mL and 4 μg/mL against Bacillus subtilis, respectively. Furthermore, when compounds 5 and 11 were combined with two commercial antibiotics kanamycin and chloramphenicol, they showed strong synergistic activity at sub-MIC levels against S. aureus USA300 and B. subtilis 168. Moreover, chloramphenicol turned from a bacteriostatic to a bactericidal agent when combined with compound 11 against B. subtilis 168.
- Subject
- antibacterial activity; ocotillol-type; synergistic effect; triterpenoid saponin
- Identifier
- http://hdl.handle.net/1959.13/1303171
- Identifier
- uon:20628
- Identifier
- ISSN:1747-0277
- Rights
- This is the peer reviewed version of the following article: Bi, Yi; Ma, Cong; Zhang, Hengyuan; Zhou, Zhiwen; Yang, Jian; Zhang, Zhenlei; Meng, Qingguo; Lewis, Peter J.; Xu, Jinyi. "Novel 3-substituted ocotillol-type triterpenoid derivatives as antibacterial candidates” Published in Chemical Biology and Drug Design, Vol. 84, Issue 4, p. 489-496, (2014), which has been published in final form at http://dx.doi.org/10.1111/cbdd.12337. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- Language
- eng
- Full Text
- Reviewed
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