- Title
- Inhibition of MEK sensitizes gastric cancer cells to TRAIL-induced apoptosis
- Creator
- Wu, P.; Cheng, Y. W.; Wang, J. Y.; Zhang, X. D.; Zhang, L. J.
- Relation
- Neoplasma Vol. 61, Issue 2, p. 136-143
- Publisher Link
- http://dx.doi.org/10.4149/neo_2014_019
- Publisher
- AEPress
- Resource Type
- journal article
- Date
- 2014
- Description
- Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which has long been believed to be highly selective in inducing apoptosis in cancer cells, has turned out to be a molecule that induces a far more diverse range of effects. The aim of this study was to investigate whether or not ERK1/2 pathway is involved in antitumor effects of TRAIL on gastric cancer cells. In addition to activate the extrinsic and intrinsic apoptotic pathway, TRAIL also triggered the activation of ERK1/2. Inhibition of ERK1/2 signaling by MEK inhibitor U0126 promoted cell death via increased activation of caspases, drop in mitochondrial membrane potential and downregulation of XIAP, cIAP2 and Mcl-1. These results indicate that TRAIL-induced rapid activation of ERK1/2 may be a survival mechanism to struggle against TRAIL assault at the early stage, and inhibition of ERK1/2 signaling can sensitize gastric cancer cells to TRAIL-induced apoptosis.
- Subject
- gastric cancer; TRAIL; ERK1/2; apoptosis
- Identifier
- http://hdl.handle.net/1959.13/1302894
- Identifier
- uon:20568
- Identifier
- ISSN:0028-2685
- Language
- eng
- Reviewed
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