Inhibition of MEK sensitizes gastric cancer cells to TRAIL-induced apoptosis

Title: Inhibition of MEK sensitizes gastric cancer cells to TRAIL-induced apoptosis
Creator: Wu, P.; Cheng, Y. W.; Wang, J. Y.; Zhang, X. D.; Zhang, L. J.
Relation: Neoplasma Vol. 61, Issue 2, p. 136-143
Publisher Link: http://dx.doi.org/10.4149/neo_2014_019
Publisher: AEPress
Resource Type: journal article
Date: 2014
Description: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which has long been believed to be highly selective in inducing apoptosis in cancer cells, has turned out to be a molecule that induces a far more diverse range of effects. The aim of this study was to investigate whether or not ERK1/2 pathway is involved in antitumor effects of TRAIL on gastric cancer cells. In addition to activate the extrinsic and intrinsic apoptotic pathway, TRAIL also triggered the activation of ERK1/2. Inhibition of ERK1/2 signaling by MEK inhibitor U0126 promoted cell death via increased activation of caspases, drop in mitochondrial membrane potential and downregulation of XIAP, cIAP2 and Mcl-1. These results indicate that TRAIL-induced rapid activation of ERK1/2 may be a survival mechanism to struggle against TRAIL assault at the early stage, and inhibition of ERK1/2 signaling can sensitize gastric cancer cells to TRAIL-induced apoptosis.
Subject: gastric cancer; TRAIL; ERK1/2; apoptosis
Identifier: http://hdl.handle.net/1959.13/1302894
Identifier: uon:20568
Identifier: ISSN:0028-2685
Language: eng
Reviewed

		Thumbnail	File	Description	Size	Format