- Title
- Pneumococcal vaccination may induce anti-oxidized low-density lipoprotein antibodies that have potentially protective effects against cardiovascular disease
- Creator
- Suthers, B.; Hansbro, P. M.; Thambar, S.; McEvoy, M. A.; Peel, R.; Attia, J. R.
- Relation
- Vaccine Vol. 30, Issue 27, p. 3983-3985
- Publisher Link
- http://dx.doi.org/10.1016/j.vaccine.2012.03.084
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2012
- Description
- Many animal and human studies have found an inverse association between anti-oxidized low-density lipoprotein (oxLDL) antibodies (anti-oxLDL) and atherosclerotic burden. Furthermore, anti-oxLDL antibodies have been shown to cause regression of atherosclerotic plaque in mice. Animal studies indicate that the 23-valent pneumococcal vaccine may induce the production of these potentially protective anti-oxLDL antibodies, and human epidemiological studies support their potentially beneficial effect in reducing cardiovascular events. Here we describe the association between self-reported pneumococcal vaccination, vaccination verified by linkage to health records, and anti-pneumococcal antibody titers, and anti-ox-LDL titers in a group of 116 older people. We found a bimodal distribution of anti-oxLDL antibodies, and a significant association between pneumococcal IgG and anti-oxLDL antibody titers that remained after multivariate adjustment for potential confounders (p = 0.04). There was no significant association between self-reported vaccination or vaccination verified by health record linkage and ox-LDL titers, which may be due to reporting error or variability in response to the vaccine. These results support a mechanistic link between pneumococcal vaccination and a potential protective effect on cardiovascular disease, and indicate that self-reported or verified vaccine status may not be sufficient to detect this association.
- Subject
- pneumococcal vaccine; ox-LDL; anti-oxLDL antibodies; cardiovascular disease
- Identifier
- http://hdl.handle.net/1959.13/1301990
- Identifier
- uon:20387
- Identifier
- ISSN:0264-410X
- Language
- eng
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