- Title
- Contribution of bone marrow derived cells to the pancreatic tumor microenvironment
- Creator
- Scarlett, Christopher J.
- Relation
- Frontiers in Physiology Vol. 4, p. 1-7
- Publisher Link
- http://dx.doi.org/10.3389/fphys.2013.00056
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2013
- Description
- Pancreatic cancer is a complex, aggressive, and heterogeneous malignancy driven by the multifaceted interactions within the tumor microenvironment. While it is known that the tumor microenvironment accommodates many cell types, each playing a key role in tumorigenesis, the major source of these stromal cells is not well-understood. This review examines the contribution of bone marrow-derived cells (BMDC) to pancreatic carcinogenesis, with respect to their role in constituting the tumor microenvironment. In particular, theirrole in supporting fibrosis, immunosuppression, and neovascularization will be discussed.
- Subject
- bone marrow derived stem cells; pancreatic cancer; stroma; pancreatic stellate cells; fibrosis; immunosuppression; neovascularization
- Identifier
- http://hdl.handle.net/1959.13/1300721
- Identifier
- uon:20127
- Identifier
- ISSN:1664-042X
- Language
- eng
- Full Text
- Reviewed
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1 MB | Adobe Acrobat PDF | View Details Download |