Expanding the utility of flow hydrogenation - a robust protocol restricting hydrodehalogenation

Title: Expanding the utility of flow hydrogenation - a robust protocol restricting hydrodehalogenation
Creator: Hizartzidis, Lacey; Cossar, Peter J.; Robertson, Mark J.; Simone, Michela I.; Young, Kelly A.; McCluskey, Adam; Gordon, Christopher P.
Relation: ARC
Relation: RSC Advances Vol. 4, Issue 100, p. 56743-56748
Publisher Link: http://dx.doi.org/10.1039/c4ra09605c
Publisher: Royal Society of Chemistry
Resource Type: journal article
Date: 2014
Description: A commonly observed limitation of conducting hydrogenations under flow chemistry conditions is hydrodehalogenation. In a bid to circumvent this limitation a series of hydrogenation catalysts were screened, with 5% Pt/C (sulfided) catalyst identified as an effective catalyst to selectively effect reductive aminations, nitro reduction, and alkene reductions in the presence of halogen atoms. Additionally the optimised protocol cleanly reduced imines in the presence of a furan moiety indicating potential amenability to other labile functionalities.
Subject: flow hydrogenation; hydrodehalogenation; hydrogenation catalysts; protocol
Identifier: http://hdl.handle.net/1959.13/1299311
Identifier: uon:19846
Identifier: ISSN:2046-2069
Language: eng
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