- Title
- Performance limitations arising in closed loop control of blood glucose in type 1 diabetes
- Creator
- Carrasco, Diego S.; Fu, Yongji; Goodwin, Graham C.; King, Bruce R.; Medioli, Adrian M.
- Relation
- 19th World Congress of the International Federation of Automatic Control (IFAC 2014). Proceedings of the 19th IFAC World Congress, 2014 (Cape Town, South Africa 24-29 August, 2014) p. 2082-2087
- Publisher Link
- http://dx.doi.org/10.3182/20140824-6-ZA-1003.02070
- Publisher
- International Federation of Automatic Control (IFAC)
- Resource Type
- conference paper
- Date
- 2014
- Description
- This paper presents a preliminary study of performance limitations that arise in the closed-loop control of blood glucose, using an autonomous artificial pancreas. It is shown that a major source of limitations is due to model uncertainty, specifically due to the combined effect of the insulin infusion system (IIS), the continuous glucose monitor (CGM) and the human glucose regulatory system. It is argued that the uncertainty associated with each of these elements compromises the achievable closed-loop bandwidth, and, in the presence of disturbances, e.g. meal intake and exercise, the closed-loop response will necessarily be poor. A proposition to overcome this problem is given based on feedforward action.
- Subject
- diabetes; artifical pancreas; blood glucose regulation; performance limitations
- Identifier
- http://hdl.handle.net/1959.13/1297417
- Identifier
- uon:19441
- Identifier
- ISBN:9783902823625
- Language
- eng
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