- Title
- Complicated and uncomplicated peptic ulcer disease: altered symptom response to a nutrient challenge linked to gastric motor dysfunction
- Creator
- Gururatsakul, M.; Holloway, R. H.; Bellon, M.; Bartholomeusz, D.; Talley, N. J.; Holtmann, G. J.
- Relation
- Digestion Vol. 89, Issue 3, p. 239-246
- Publisher Link
- http://dx.doi.org/10.1159/000360635
- Publisher
- S. Karger AG
- Resource Type
- journal article
- Date
- 2014
- Description
- Background: Bleeding peptic ulcer (BPU) frequently occurs in the absence of preceding dyspeptic symptoms. We have observed that patients with BPU had a diminished symptom response to nutrient challenge test compared to uncomplicated peptic ulcer disease (uPUD). We postulated that more symptoms are manifest in patients with uPUD than BPU because there are greater derangements in gastric motor function. Aim: To assess gastric emptying in patients with BPU, uPUD and healthy controls (HC). Methods: We studied 17 patients with BPU, 10 with uPUD, and 15 HC. After an 8-hour fast, subjects ingested 200 ml of an enteral feeding solution, containing 5 MBq ⁹⁹mTc-rhenium sulphide colloid, every 5 min up to a cumulative volume of 800 ml. Gastric emptying was measured by scintigraphy for the total, proximal and distal stomach. Results: Patients with uPUD had significantly higher gastric retention in the proximal and total stomach at 100 min than HC and BPU, while BPU had similar percent retention to HC. Patients with uPUD had significantly higher cumulative symptom response to the nutrient challenge than did HC and BPU, while BPU had similar symptom responses to HC. Conclusions: Patients with uPUD have significantly delayed gastric emptying compared to HC and BPU. Data suggest that in addition to alterations of visceral sensory function, altered gastric motor function occurs during a nutrient challenge in uPUD but not BPU. Gastric motor function may contribute to the manifestation of dyspeptic symptoms in PUD.
- Subject
- peptic ulcer disease; nutrient challenge test; gastric motor dysfunction
- Identifier
- http://hdl.handle.net/1959.13/1297377
- Identifier
- uon:19438
- Identifier
- ISSN:0012-2823
- Language
- eng
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