- Title
- Effects of long-term omega-3 polyunsaturated fatty acid supplementation on paroxysmal atrial tachyarrhythmia burden in patients with implanted pacemakers: results from a prospective randomised study
- Creator
- Kumar, Saurabh; Sutherland, Fiona; Stevenson, Irene; Lee, Justin M. S.; Garg, Manohar L.; Sparks, Paul B.
- Relation
- International Journal of Cardiology Vol. 168, Issue 4, p. 3812-3817
- Publisher Link
- http://dx.doi.org/10.1016/j.ijcard.2013.06.030
- Publisher
- Elsevier Ireland
- Resource Type
- journal article
- Date
- 2013
- Description
- Background: Sino-atrial node disease and aging increase AF risk. We investigated if long-term fish oil supplementation reduces paroxysmal atrial tachycardia/fibrillation (AT/AF) burden in patients aged = 60 years with sinoatrial node disease and dual chamber pacemakers. Methods: Following a run-in period of 6 months (p1) where AT/AF burden was logged,78 patients were randomised to control or fish oil group(total omega-3 6 g/d) and AT/AF burden evaluated after 6 months(p2; 39 controls, 39 fish oil) and 12 months (p3; 39 controls; 18 fish oil). A subset of 21 fish oil patients crossed over to controls in the final 6 months (crossover group). Results: Median AT/AF burden increased significantly in controls (1.5%, 3.2%, 4.3%, P < .001) but not in fish oil patients at 6 months (1.4% to 2%, P = .46) or those continuing for 12 months (1.5%, 0.98%, 1%, P = .16). Time to first episode of AT/AF > 1 min was not significantly different between the groups (P = .9). There was a rebound increase in AT/AF burden in p3 in cross over patients (2.2% to 5.8%, P = .01) reaching a level similar to controls (crossover vs. controls, 5.8% vs. 4.3%, P = .63) and higher than those who continued fish oil for 12 months (crossover vs. continued intake 5.8% vs. 1.2%, P = .02). Fish oil patients had shorter duration episodes of AT/AF with no difference in frequency compared to controls. Conclusion: Long-term fish oil supplementation did not suppress AT/AF burden but may have attenuated its temporal progression related to aging and sinus node disease.
- Subject
- atrial fibrillation; atrial flutter; fish oil; omega-3 polyunsaturated fatty acids; permanent pacemakers; sinus node dysfunction
- Identifier
- http://hdl.handle.net/1959.13/1296994
- Identifier
- uon:19351
- Identifier
- ISSN:0167-5273
- Language
- eng
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