- Title
- Outcomes using lower vs higher hemoglobin thresholds for red blood cell transfusion
- Creator
- Carson, Jeffrey L.; Carless, Paul A.; Hébert, Paul C.
- Relation
- Journal of the American Medical Association Vol. 309, Issue 1, p. 83-84
- Publisher Link
- http://dx.doi.org/10.1001/jama.2012.50429
- Publisher
- American Medical Association
- Resource Type
- journal article
- Date
- 2013
- Description
- Clinical Question: Is a lower vs higher hemoglobin threshold best for minimizing both red blood cell use and adverse clinical outcomes when used to trigger red blood cell transfusions in anemic patients in critical care and acute care settings? Bottom Line: Compared with higher hemoglobin thresholds, a hemoglobin threshold of 7 or 8 g/dL is associated with fewer red blood cell units transfused without adverse associations with mortality, cardiac morbidity, functional recovery, or length of hospital stay. The optimal hemoglobin/hematocrit criterion for transfusion remains controversial in several clinical settings. New evidence may best guide clinical practice. This updated Cochrane evidence includes 9 additional studies summarizing a total of 19 randomized controlled clinical trials involving more than 6000 patients that compared clinical outcomes between strategies using a higher vs lower hemoglobin/hematocrit threshold for red blood cell transfusion.
- Subject
- hemoglobin thresholds; red blood cell transfusions; anemic patients
- Identifier
- http://hdl.handle.net/1959.13/1295736
- Identifier
- uon:19106
- Identifier
- ISSN:0098-7484
- Language
- eng
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