Eosinophils: changing perspectives in health and disease

Title: Eosinophils: changing perspectives in health and disease
Creator: Rosenberg, Helene F.; Dyer, Kimberly D.; Foster, Paul S.
Relation: Nature Reviews Immunology Vol. 13, Issue 1, p. 9-22
Publisher Link: http://dx.doi.org/10.1038/nri3341
Publisher: Nature Publishing Group
Resource Type: journal article
Date: 2013
Description: Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector cells. Recent studies have profoundly altered this simplistic view of eosinophils and their function. New insights into the molecular pathways that control the development, trafficking and degranulation of eosinophils have improved our understanding of the immunomodulatory functions of these cells and their roles in promoting homeostasis. Likewise, recent developments have generated a more sophisticated view of how eosinophils contribute to the pathogenesis of different diseases, including asthma and primary hypereosinophilic syndromes, and have also provided us with a more complete appreciation of the activities of these cells during parasitic infection.
Subject: Eosinophils; changing perspectives; degranulation; molecular pathways
Identifier: http://hdl.handle.net/1959.13/1295316
Identifier: uon:18997
Identifier: ISSN:1474-1733
Language: eng
Reviewed

		Thumbnail	File	Description	Size	Format