Simple topology: FtsK-directed recombination at the dif site

Title: Simple topology: FtsK-directed recombination at the dif site
Creator: Grainge, Ian
Relation: NHMRC and ARC.APP1005697, APP1021479 & DP110102476
Relation: Biochemical Society. Transactions Vol. 41, p. 595-600
Publisher Link: http://dx.doi.org/10.1042/BST20120299
Publisher: Portland Press
Resource Type: journal article
Date: 2013
Description: FtsK is a multifunctional protein, which, in Escherichia coli, co-ordinates the essential functions of cell division, DNA unlinking and chromosome segregation. Its C-terminus is a DNA translocase, the fastest yet characterized, which acts as a septum-localized DNA pump. FtsK's C-terminus also interacts with the XerCD site-specific recombinases which act at the dif site, located in the terminus region. The motor domain of FtsK is an active translocase in vitro, and, when incubated with XerCD and a supercoiled plasmid containing two dif sites, recombination occurs to give unlinked circular products. Despite years of research the mechanism for this novel form of topological filter remains unknown.
Subject: dif; escherichia coli; FtsK; recombination; topology; XerCD
Identifier: http://hdl.handle.net/1959.13/1067291
Identifier: uon:18361
Identifier: ISSN:0300-5127
Language: eng
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