2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

Title: 2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion
Creator: Sayer, James R.; Walldén, Karin; Waksman, Gabriel; Tabor, Alethea B.; Pesnot, Thomas; Campbell, Frederick; Gane, Paul J.; Simone, Michela; Koss, Hans; Buelens, Floris; Boyle, Timothy P.; Selwood, David L.
Relation: Bioorganic and Medicinal Chemistry Vol. 22, Issue 22, p. 6459-6470
Publisher Link: http://dx.doi.org/10.1016/j.bmc.2014.09.036
Publisher: Elsevier
Resource Type: journal article
Date: 2014
Description: A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhibitors, which show potential as antibacterial agents.
Subject: 8-Amino imidazo[1,2-a]pyrazine; bacterial type IV secretion system; HP0525; ATPase inhibitor
Identifier: http://hdl.handle.net/1959.13/1065975
Identifier: uon:18018
Identifier: ISSN:0968-0896
Language: eng
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