- Title
- Measurement of FEF25–75% and FEF75% does not contribute to clinical decision making
- Creator
- Quanjer, Philip H.; Weiner, Daniel J.; Pretto, Jeffrey J.; Brazzale, Danny J.; Boros, Piotr W.
- Relation
- European Respiratory Journal Vol. 43, Issue 4, p. 1051-1058
- Publisher Link
- http://dx.doi.org/10.1183/09031936.00128113
- Publisher
- European Respiratory Society
- Resource Type
- journal article
- Date
- 2014
- Description
- The aim of this study was to determine the added value of measuring the forced expiratory flow at 25-75% of forced vital capacity (FVC) (FEF25-75%) and flow when 75% of FVC has been exhaled (FEF75%) over and above the measurement of the forced expiratory volume in 1 s (FEV1), FVC and FEV1/FVC ratio. We used spirometric measurements of FEV1>, FVC and FEF25-75% from 11654 white males and 11113 white females, aged 3-94 years, routinely tested in the pulmonary function laboratories of four tertiary hospitals. FEF75% was available in 8254 males and 7407 females. Predicted values and lower limits of normal, defined as the fifth percentile, were calculated for FEV1, FVC, FEV1/FVC ratio, FEF25-75% and FEF75% using prediction equations from the Global Lung Function Initiative. There was very little discordance in classifying test results. FEF25-75% and FEF75% were below the normal range in only 2.75% and 1.29% of cases, respectively, whereas FEV1, FVC and FEV1/FVC ratio were within normal limits. Airways obstruction went undetected by FEF25-75% in 2.9% of cases and by FEF75% in 12.3% of cases. Maximum mid-expiratory flow and flow towards the end of the forced expiratory manoeuvre do not contribute usefully to clinical decision making over and above information from FEV1, FVC and FEV1/FVC ratio.
- Subject
- clinical decision making; forced expiratory volume; Global Lung Function Initiative; forced expiratory flow
- Identifier
- http://hdl.handle.net/1959.13/1064262
- Identifier
- uon:17502
- Identifier
- ISSN:0903-1936
- Language
- eng
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