A flow chemistry approach to norcantharidin analogues

Title: A flow chemistry approach to norcantharidin analogues
Creator: Tarleton, Mark; Young, Kelly A.; Unicomb, Eli; McCluskey, Siobahnn N.; Robertson, Mark J.; Gordon, Christopher P.; McCluskey, Adam
Relation: Letters in Drug Design and Discovery Vol. 8, Issue 6, p. 568-574
Publisher Link: http://dx.doi.org/10.2174/157018011795906730
Publisher: Bentham Science Publishers
Resource Type: journal article
Date: 2011
Description: Acid-ester and acid-amide norcantharidin derivatives are prepared using a ‘one-pot’ synthetic procedure utilizing the ThalesNano H-cube™ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.
Subject: cantharidin; norcantharidin; H-cube; kinomics; acetone; acid ester; nucleophilicity; flow hydrogenation; flow chemistry; protein phosphatase inhibition; anti-malarial; anti-parasitic; Diels; Alder; Parr hydrogenation
Identifier: http://hdl.handle.net/1959.13/1063991
Identifier: uon:17426
Identifier: ISSN:1570-1808
Language: eng
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