- Title
- The role of molecular regulation and targeting in regulating calcium/calmodulin stimulated protein kinases
- Creator
- Skelding, Kathryn A.; Rostas, John A. P.
- Relation
- Calcium Signaling p. 703-730
- Relation
- Advances in Experimental Medicine and Biology 740
- Publisher Link
- http://dx.doi.org/10.1007/978-94-007-2888-2_31
- Publisher
- Springer New York
- Resource Type
- book chapter
- Date
- 2012
- Description
- Calcium/calmodulin-stimulated protein kinases can be classified as one of two types – restricted or multifunctional. This family of kinases contains several structural similarities: all possess a calmodulin binding motif and an autoinhibitory region. In addition, all of the calcium/calmodulin-stimulated protein kinases examined in this chapter are regulated by phosphorylation, which either activates or inhibits their kinase activity. However, as the multifunctional calcium/calmodulin-stimulated protein kinases are ubiquitously expressed, yet regulate a broad range of cellular functions, additional levels of regulation that control these cell-specific functions must exist. These additional layers of control include gene expression, signaling pathways, and expression of binding proteins and molecular targeting. All of the multifunctional calcium/calmodulin-stimulated protein kinases examined in this chapter appear to be regulated by these additional layers of control, however, this does not appear to be the case for the restricted kinases.
- Subject
- phosphorylase kinase; eEF2K; myosin light chain kinase; CaMKK; CaMKI; CaMKII; CaMKIV; casein kinase I; targeting
- Identifier
- http://hdl.handle.net/1959.13/1062119
- Identifier
- uon:17046
- Identifier
- ISBN:9789400728875
- Language
- eng
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