- Title
- Hyperlipidemia
- Creator
- Kostrilis, Vicki; Garg, Manohar
- Relation
- A Guide to Evidence-based Integrative and Complementary Medicine p. 444-470
- Relation
- http://www.elsevierhealth.com.au/physical-medicine-and-rehabilitation/a-guide-to-evidence-based-integrative-and-complementary-medicine-paperback/9780729539081/
- Publisher
- Churchill Livingstone Australia
- Resource Type
- book chapter
- Date
- 2011
- Description
- Hyperlipidemia is a heterogeneous disorder characterised by increased circulating levels of plasma cholesterol, low-density lipoprotein (LDL)-cholesterol, triglycerides and apolipoprotein-B (apoB) as well as reduced high-density lipoprotein (HDL)-cholestero concentration. The primary lipid abnormality involved in the development of hyperlipidemia is an increase in circulating free (non-esterified) fatty acids originating from adipose tissue, caused by a down-regulation of signalling pathways, as well as inadequate esterification and metabolism. Reduced retention of fatty acids by adipose tissue results in an increased flux of non-esterified or free fatty acids (FFA) returning to the liver, stimulating hepatic triglyceride synthesis, promoting production of apoB and assembly/secretion of very low-density lipoprotein (VLDL). Presence of increased plasma triglyceride concentration results in the increased production of triglyceride rich HDL particles that are more likely to be catabolized resulting in reduced HDL-cholesterol. Elevated VLDL particles are lipolyses, converted into small dense (highly atherogenic) LDL particles with reduced receptor-mediated clearance, prolonged retention in circulation and an increased suscepribiliry to peroxidarion. A strong independent association berween elevated levels of LDL-cholesterol and increased incidence of coronary heart disease (CHD) has been established .
- Subject
- hyperlipidemia; cholesterol; heart disease
- Identifier
- http://hdl.handle.net/1959.13/1061556
- Identifier
- uon:16973
- Identifier
- ISBN:9780729539081
- Language
- eng
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