- Title
- MicroRNA: potential biomarkers and therapeutic targets for allergic asthma?
- Creator
- Tay, Hock L.; Plank, Maximillan; Collison, Adam; Mattes, Joerg; Kumar, Rakesh K.; Foster, Paul S.
- Relation
- Annals of Medicine Vol. 46, Issue 8, p. 633-639
- Publisher Link
- http://dx.doi.org/10.3109/07853890.2014.958196
- Publisher
- Informa Healthcare
- Resource Type
- journal article
- Date
- 2014
- Description
- MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and diff erentiation). However, alterations in their levels may compromise cellular function, predisposing to disease. In this review, we discuss microRNAs that have been linked with pathogenesis of asthma and propose functional roles in the regulation of disease. MicroRNAs have the potential to be biomarkers for asthma and provide the platform for the development of new classes of therapeutic compounds.
- Subject
- allergy; asthma; inflammation; lung; microRNAs
- Identifier
- http://hdl.handle.net/1959.13/1061138
- Identifier
- uon:16891
- Identifier
- ISSN:0785-3890
- Language
- eng
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