- Title
- Fasting whole blood fatty acid profile and risk of type 2 diabetes in adults: a nested case control study
- Creator
- Alhazmi, Amani; Stojanovski, Elizabeth; Garg, Manohar L.; McEvoy, Mark
- Relation
- PLoS ONE Vol. 9, Issue 5
- Publisher Link
- http://dx.doi.org/10.1371/journal.pone.0097001
- Publisher
- Public Library of Science
- Resource Type
- journal article
- Date
- 2014
- Description
- Objective: to determine the association of fasting whole blood fatty acid concentrations with incidence of type 2 diabetes in adults. Methods: A nested case-control study of 187 subjects from a cohort of men and women aged 55–85 years from the Hunter Region, New South Wales, Australia. Fasting whole blood fatty acids were measured using gas chromatography and incidence of type 2 diabetes was ascertained by self-reported questionnaire at the study follow-up. Results: After adjustment for potential confounding variables, positive associations with type 2 diabetes were seen for dihomo-gamma-linolenic acid (DGLA) (OR = 1.04, 95% CI:1.01–1.07, P = 0.01); arachidonic acid (ARA) (OR = 1.01, 95% CI:1.00–1.01, P = 0.002); alpha-linolenic acid (ALA) (OR = 1.10, 95% CI: 1.03–1.18, P = 0.01); eicosapentaenoic acid (EPA) (OR = 1.05, 95% CI:1.02–1.08, P = 0.001); and docosahexaenoic acid (DHA) (OR = 1.03, 95% CI:1.02–1.05, P,0.0001). Lignoceric acid is significantly associated with lower type 2 diabetes risk (OR = 0.95, 95% CI: 0.92–0.99, P = 0.01). Conclusion: These data suggest that higher fasting whole blood concentrations of omega-6 polyunsaturated fatty acids (n-6PUFA) (ARA and DGLA) as well as omega-3 polyunsaturated fatty acid (n-3PUFA) (ALA, EPA, and DHA) are associated with an increased risk of diabetes, whereas increased fasting whole blood concentrations of lignoceric acid is inversely associated with diabetes risk.
- Subject
- fatty acids; type 2 diabetes; blood; type 2 diabetes risk; blood plasma; biomarkers; carbohydrates; cohort studies
- Identifier
- http://hdl.handle.net/1959.13/1060716
- Identifier
- uon:16813
- Identifier
- ISSN:1932-6203
- Language
- eng
- Full Text
- Reviewed
- Hits: 9479
- Visitors: 2821
- Downloads: 443
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Publisher version (open access) | 182 KB | Adobe Acrobat PDF | View Details Download |