- Title
- Interferon-ε protects the female reproductive tract from viral and bacterial infection
- Creator
- Fung, Ka Yee; Mangan, Niamh E.; Schjenken, John E.; Parker, Belinda; Gargett, Caroline E.; Nguyen, Hong P. T.; Carr, Daniel J.; Hansbro, Philip M.; Hertzog, Paul J.; Cumming, Helen; Horvat, Jay C.; Mayall, Jemma R.; Stifter, Sebastian A.; De Weerd, Nicole; Roisman, Laila C.; Rossjohn, Jamie; Robertson, Sarah A.
- Relation
- Science Vol. 339, Issue 6123, p. 1088-1092
- Publisher Link
- http://dx.doi.org/10.1126/science.1233321
- Publisher
- American Association for the Advancement of Science
- Resource Type
- journal article
- Date
- 2013
- Description
- The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-ε was not induced by known PRR pathways; instead, IFN-ε was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-ε–deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.
- Subject
- interferons; reproductive tract; infection; herpes; chlamydia
- Identifier
- http://hdl.handle.net/1959.13/1056175
- Identifier
- uon:15996
- Identifier
- ISSN:0036-8075
- Rights
- This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 339, 2013: http://dx.doi.org/10.1126/science.1233321
- Language
- eng
- Full Text
- Reviewed
- Hits: 3634
- Visitors: 4555
- Downloads: 605
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Author final version | 3 MB | Adobe Acrobat PDF | View Details Download |