The role of modifier genes in Lynch Syndrome

Title: The role of modifier genes in Lynch Syndrome
Creator: Scott, Rodney J.; Reeves, Stuart; Talseth-Palmer, Bente
Relation: Colorectal Cancer Biology From Genes To Tumor p. 37-58
Publisher Link: http://dx.doi.org/10.5772/1163
Publisher: InTech
Resource Type: book chapter
Date: 2012
Description: There are a number of inherited predispositions to colorectal cancer (CRC) which can be broadly categorized into two groups; those with associated polyposis, such as familial adenomatous polyposis and the hamartomatous polyposis syndromes; and those that are linked to the non-polyposis syndromes, such as hereditary non polyposis colorectal cancer (HNPCC). The genetic basis of both the polyposis and non-polyposis syndromes are reflected in the CRC population who have no apparent family history of disease. Approximately 80% of all cases of CRC are associated with chromosomal instability [1] and are likely to have mutations in the Adenomatous Polyposis Coli (APC) gene whereas the remaining 20% with microsatellite instability appears to be due primarily to epigenetic inactivation of the DNA mismatch repair (MMR) gene MLH1 [2].
Subject: colorectal cancer (CRC); hereditary non polyposis colorectal cancer (HNPCC); familial adenomatous polyposis
Identifier: http://hdl.handle.net/1959.13/1053683
Identifier: uon:15650
Identifier: ISBN:9789535100621
Language: eng
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