- Title
- Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults
- Creator
- Wong, Rachel H. X.; Berry, Narelle M.; Coates, Alison M.; Buckley, Jonathan D.; Bryan, Janet; Kunz, Iris; Howe, Peter R. C.
- Relation
- Journal of Hypertension Vol. 31, Issue 9, p. 1819-1827
- Publisher Link
- http://dx.doi.org/10.1097/HJH.0b013e328362b9d6
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2013
- Description
- Background: We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition. Objectives: To evaluate the effects of chronic resveratrol supplementation on both FMD and cognitive performance. Method: Twenty-eight obese but otherwise healthy adults (BMI: 33.3 +/- 0.6 kg/m2) were randomized to take a single 75 mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial. Blood pressure, arterial compliance, FMD, and performance on the Stroop Color-Word Test were assessed at the end of each 6-week intervention period while fasted and at least 18 h after taking the last daily capsule. An additional capsule of the same supplement was then taken. FMD assessment was repeated 1 h later. Results: Chronic resveratrol supplementation for 6 weeks was well tolerated and resulted in a 23% increase in FMD compared with placebo (P = 0.021, paired t-test). The extent of increase correlated negatively with baseline FMD (r = -0.47, P = 0.01). A single dose of resveratrol (75 mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD. Blood pressure, arterial compliance, and all components of the Stroop Color-Word Test were unaffected by chronic resveratrol supplementation. Conclusion: Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults.
- Subject
- bioactive nutrients; cognition; flow-mediated dilatation; obesity; resveratrol; vascular function
- Identifier
- http://hdl.handle.net/1959.13/1053417
- Identifier
- uon:15586
- Identifier
- ISSN:0263-6352
- Language
- eng
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