- Title
- Diagnosis of snake envenomation using a simple phospholipase A₂ assay
- Creator
- Maduwage, Kalana; O'Leary, Margaret A.; Isbister, Geoffrey K.
- Relation
- Scientific Reports Vol. 4
- Publisher Link
- http://dx.doi.org/10.1038/srep04827
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2014
- Description
- Diagnosis of snake envenomation is challenging but critical for deciding on antivenom use. Phospholipase A₂ enzymes occur commonly in snake venoms and we hypothesized that phospholipase activity detected in human blood post-bite may be indicative of envenomation. Using a simple assay, potentially a bedside test, we detected high phospholipase activity in sera of patients with viper and elapid envenomation compared to minimal activity in non-envenomed patients.
- Subject
- antivenom; envenomation; snake venom; phospholipase
- Identifier
- http://hdl.handle.net/1959.13/1048068
- Identifier
- uon:14867
- Identifier
- ISSN:2045-2322
- Language
- eng
- Full Text
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Publisher version (open access) | 575 KB | Adobe Acrobat PDF | View Details Download |