Intravenous paracetamol toxicity in a malnourished child

Title: Intravenous paracetamol toxicity in a malnourished child
Creator: Berling, Ingrid; Anscombe, Michael; Isbister, Geoffrey K.
Relation: Clinical Toxicology Vol. 50, Issue 1, p. 74-76
Publisher Link: http://dx.doi.org/10.3109/15563650.2011.631189
Publisher: Informa Healthcare
Resource Type: journal article
Date: 2012
Description: We present a case of intravenous (IV) paracetamol overdose in a nutritionally malnourished child during hospital admission. A ten-fold IV paracetamol dosing error occurred, with delayed recognition and treatment resulting in transient hepatotoxicity, with a peak alanine transaminase (ALT) of 1378 IU/L in a 3-year-old child. Our case suggests that hepatotoxicity may occur for lower doses of IV paracetamol compared to oral ingestion, especially in the malnourished, and that a dose less than 150 mg/kg of IV paracetamol should be used to define treatment following overdose in a child with potential nutritional deficiencies.
Subject: gut; hepatotoxicity; paracetamol; other
Identifier: http://hdl.handle.net/1959.13/1045424
Identifier: uon:14460
Identifier: ISSN:1556-3650
Language: eng
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