- Title
- Understanding probability and exposure in paracetamol overdose risk assessment
- Creator
- Isbister, Geoffrey K.; Duffull, Stephen Brent
- Relation
- Clinical Toxicology Vol. 51, Issue 10, p. 1240-1240
- Publisher Link
- http://dx.doi.org/10.3109/15563650.2013.851391
- Publisher
- Informa Healthcare
- Resource Type
- journal article
- Date
- 2013
- Description
- A number of previous studies have investigated whether dose can predict outcomes, but they do not provide a continuous probability of requiring N-acetylcysteine (NAC) versus the dose. For example, the study by Waring et al. used a single cut-off which confirms dose being a predictor but cannot guide treatment over a range of doses. This study cannot answer the question, “Do we treat with NAC at 13 g or not treat at 13 g?” Thomas et al. and Zyoud et al. reported smaller studies of 300 – 400 patients with similar single threshold cut-offs. The aim in our study was to provide a probability of requiring NAC over a large dose range to assist clinicians in making early treatment decisions. However, we do not provide a prescriptive approach to the treatment of paracetamol overdose, and in particular we do not give a definite “cut-off dose” for a “wait and see approach” . We hope the study will assist clinicians in making individual treatment decisions. A prospective study will be required to determine if using a general cut-off dose for all cases for early treatment decisions, is feasible and safe.
- Subject
- paracetemol overdose; risk assessment; toxicity
- Identifier
- http://hdl.handle.net/1959.13/1045336
- Identifier
- uon:14446
- Identifier
- ISSN:1556-3650
- Language
- eng
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