- Title
- Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
- Creator
- James, Morgan H.; Charnley, Janine L.; Levi, Emily M.; Jones, Emma; Yeoh, Jiann Wei; Smith, Douglas W.; Dayas, Christopher V.
- Relation
- International Journal of Neuropsychopharmacology Vol. 14, Issue 5, p. 684-690
- Publisher Link
- http://dx.doi.org/10.1017/S1461145711000423
- Publisher
- Cambridge University Press
- Resource Type
- journal article
- Date
- 2011
- Description
- Orexinergic signalling is critical to drug relapse-like behaviour; however, the CNS sites(s) of action remain unknown. Two candidate brain regions are the paraventricular thalamus (PVT) and ventral tegmental area (VTA). We assessed the effect of intra-PVT or -VTA administration of the orexin-1 receptor (OrxR1) antagonist SB-334867 on discriminative cue-induced cocaine-seeking. Animals received either PVT- or VTA-directed SB-334867 (0, 3 or 6 mg; 0, 1 or 3 μg, respectively) prior to reinstatement testing elicited by presenting cocaine-paired stimuli (S+). The effect of VTA-directed injections of SB-334867 (0 or 3 μg) on locomotor activity was also assessed. Intra-VTA, but not -PVT, SB-334867 dose-dependently attenuated S+-induced reinstatement (3 μg dose, p<0.01). Intra-VTA SB-334867 had no effect on locomotor activity. We conclude that OrxR1 signalling within the VTA, but not the PVT, mediates cue-induced cocaine-seeking behaviour. We hypothesize that blockade of VTA OrxR1 signalling may reduce nucleus accumbens dopamine in response to drug cue presentation.
- Subject
- cocaine; orexin; paraventricular thalamus; relapse; ventral tegmental area
- Identifier
- http://hdl.handle.net/1959.13/1044589
- Identifier
- uon:14350
- Identifier
- ISSN:1461-1457
- Language
- eng
- Full Text
- Reviewed
- Hits: 2132
- Visitors: 2813
- Downloads: 347
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Publisher version (open access) | 377 KB | Adobe Acrobat PDF | View Details Download |