- Title
- Relationship between the retinal microvasculature and renal volume in low-birth-weight babies
- Creator
- Kandasamy, Yogavijayan; Smith, Roger; Wright, Ian M. R.
- Relation
- American Journal of Perinatology Vol. 30, Issue 6, p. 477-482
- Publisher Link
- http://dx.doi.org/10.1055/s-0032-1326993
- Publisher
- Thieme Medical Publishers
- Resource Type
- journal article
- Date
- 2013
- Description
- We performed a study to assess whether the development of the retinal microvasculature reflects nephron growth and therefore nephron number. In our study, we determined the association between kidney volume (nephron number) and the retinal microvasculature of term low-birth-weight (LBW) and normal-birth-weight (NBW) infants (11 LBW and 27 NBW). LBW infants had significantly larger retinal arteriolar and venular diameters (104.2 ± 21.4 versus 87.0 ± 12.7 μm; p = 0.004; 146.8 ± 19.5 versus 128.0 ± 19.5 μm; p = 0.01, respectively) compared with NBW infants. LBW infants also had smaller mean renal volumes (9.3 ± 2.3 versus 12.2 ± 3.1 ml; p = 0.008). There were negative correlations between retinal arteriolar and venular diameters and renal volumes (r = −0.34, p < 0.05; r = −0.37, p < 0.05, respectively). The larger the kidney (and, by implication, the greater the nephron number), the smaller are the diameters of retinal arterioles and venules. Thus, the degree of dilation of the retinal microvasculature provides an indirect index of renal growth.
- Subject
- retinal vessels; renal volume; neonate; low birth weight
- Identifier
- http://hdl.handle.net/1959.13/1037043
- Identifier
- uon:13396
- Identifier
- ISSN:0735-1631
- Language
- eng
- Full Text
- Reviewed
- Hits: 1021
- Visitors: 1437
- Downloads: 229
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT03 | Author final version | 467 KB | Adobe Acrobat PDF | View Details Download |