- Title
- Measuring cystatin C to determine renal function in neonates
- Creator
- Kandasamy, Yogavijayan; Smith, Roger; Wright, Ian M. R.
- Relation
- Pediatric Critical Care Medicine Vol. 14, Issue 3, p. 318-322
- Publisher Link
- http://dx.doi.org/10.1097/PCC.0b013e318271f4a5
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2013
- Description
- Objectives: The incidence of acute kidney injury in neonates is high and associated with up to a 50% mortality rate. The purpose of this review was to determine the feasibility of using serum cystatin C measurements to assist clinicians in making early and accurate diagnoses of acute kidney injury in neonates. Data Source: We searched for the following seven key words within the PubMed database and the Cochrane Database of Systematic Reviews: cystatin C, neonates, newborn, preterm, premature, kidney failure, and kidney injury. Study Selection: The selected studies included neonates within their study populations and were published in English. We reviewed literature published between January 1990 and May 2012. Data Extraction: Ten studies had conducted serum cystatin C measurements in neonates. Data Synthesis: The cystatin C level in neonates is not influenced by the maternal level and is highest at birth. In most studies, cystatin C levels on day 1 of life ranged between 1 and 2 mg/L, gradually declined during the first year and then remained relatively stable thereafter. Cystatin C levels did not differ between male and female infants, and no significant gestational age-dependent differences were found. Cystatin C levels were increased in cases of sepsis, acute kidney injury, and congenital renal abnormalities. Conclusions: Cystatin C has all of the theoretical properties needed to be an ideal marker of renal function. It can be used to determine baseline renal function on day 1 and is increasingly being used to determine renal function in sick neonates. In the majority of studies, the day 1 cystatin C level ranged between 1 and 2 mg/L, which gradually declined in the first year of life. However, the number of available studies evaluating cystatin C in sick neonates is currently limited, and there are also no studies linking cystatin C levels in sick babies with short-term and long-term outcomes.
- Subject
- acute kidney injury; creatinine; cystatin C; neonates; preterm; renal failure
- Identifier
- http://hdl.handle.net/1959.13/1036882
- Identifier
- uon:13373
- Identifier
- ISSN:1529-7535
- Language
- eng
- Full Text
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