- Title
- Noninvasive assessment of inflammation in severe asthma
- Creator
- Gibson, P. G.; Wang, F.; He, X. Y.; Brightling, C. E.
- Relation
- Difficult-to-Treat Severe Asthma p. 208-217
- Publisher Link
- http://dx.doi.org/10.1183/1025448x.10002110
- Publisher
- European Respiratory Society
- Resource Type
- book chapter
- Date
- 2011
- Description
- Severe asthma is characterised by heterogeneity at the level of both clinical expression and disease mechanisms. Airway inflammation is a key component of severe asthma and is heterogeneous in its pattern. This heterogeneity indicates different underlying disease mechanisms and treatment responses in severe asthma. There are a range of sampling procedures and biomarkers that are available for the noninvasive assessment of airway inflammation in severe asthma. Induced sputum has been extensively studied; however, other markers have undergone only limited evaluation of their clinical utility. Induced sputum markers for the identification of eosinophilic and non-eosinophilic inflammatory patterns are useful in predicting exacerbation risk and identifying potential treatment responses. Future work aimed at improving sampling methodologies and identifying biomarkers that are suitable for fast-throughput or automated assay platforms would add significantly to the noninvasive assessment of airway inflammation in severe asthma.
- Subject
- eosinophil; induced sputum; nitric oxide; non-eosinophilic; paucigranulocytic; severe asthma
- Identifier
- http://hdl.handle.net/1959.13/1036600
- Identifier
- uon:13322
- Identifier
- ISBN:9781849840095
- Language
- eng
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