- Title
- Role of central 5-hydroxytryptamine nerves in tonic, thermal and arterial chemoreflex control of ear vessel sympathetic innervation
- Creator
- White, Saxon William; Traugott, F. M.; Heath, J. W.; Quail, A. W.; Smart, J. F.
- Relation
- Journal of the Autonomic Nervous System Vol. Suppl., p. 535-541
- Relation
- http://www.sciencedirect.com/science/journal/01651838
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 1986
- Description
- The role of central (CNS) 5-hydroxytryptamine (5-HT) nerves in the thermal and arterial chemoreflex control of sympathetic innervation of ear skin vessels was studied in groups of unanesthetized normal, CNS 5-HT deplete (intracisternal 5,7-dihydroxytryptamine injection) and pontine rabbits. Ear artery flow (and conductance) was measured by a Doppler transducer. The high vasomotor tone in the ear skin of normal animals at rest was inhibited by the arterial chemoreflex and warm environment. It was absent, however, at rest in CNS 5-HT deplete animals. In pontine rabbits the resting high vasomotor tone was not inhibited by the arterial chemoreflex or a warm environment. These data suggest that bulbospinal 5-HT nerves have a major excitatory influence on tonic sympathetic activity to ear vessels, and that the central inhibition of this activity by arterial chemoreflex and environmental warmth involves suprabulbar influences and a transmitter other than 5-HT.
- Subject
- central nervous system; 5-hydroxytryptamine; arterial chemoreflex; temperature regulation; sympathetic nerves; ear skin circulation
- Identifier
- http://hdl.handle.net/1959.13/939861
- Identifier
- uon:12890
- Identifier
- ISSN:0165-1838
- Language
- eng
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