Pulmonary-intestinal cross-talk in mucosal inflammatory disease

Title: Pulmonary-intestinal cross-talk in mucosal inflammatory disease
Creator: Keely, S.; Talley, N. J.; Hansbro, P. M.
Relation: Mucosal Immunology Vol. 5, Issue 1, p. 7-18
Publisher Link: http://dx.doi.org/10.1038/mi.2011.55
Publisher: Nature Publishing Group
Resource Type: journal article
Date: 2012
Description: Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of mucosal tissues that affect the respiratory and gastrointestinal tracts, respectively. They share many similarities in epidemiological and clinical characteristics, as well as in inflammatory pathologies. Importantly, both conditions are accompanied by systemic comorbidities that are largely overlooked in both basic and clinical research. Therefore, consideration of these complications may maximize the efficacy of prevention and treatment approaches. Here, we examine both the intestinal involvement in COPD and the pulmonary manifestations of IBD. We also review the evidence for inflammatory organ cross-talk that may drive these associations, and discuss the current frontiers of research into these issues.
Subject: chronic obstructive pulmonary disease; COPD; inflammatory bowel disease; IBD
Identifier: http://hdl.handle.net/1959.13/939316
Identifier: uon:12772
Identifier: ISSN:1933-0219
Language: eng
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