- Title
- Haemodynamic effects of arrhythmias : effects of alterations in ventricular rate on cardiac output and peripheral flow distribution
- Creator
- White, Saxon William; Porges, William L.; McRitchie, Robert J.; Reid, John V. O.
- Relation
- Advances in Cardiolgy Vol. 12, p. 266-278
- Publisher
- S. Karger
- Resource Type
- journal article
- Date
- 1974
- Description
- Changes in ventricular rate that occur normally are predominantly autonomically directed and form part of a co-ordinated pattern of autonomic effects evoked by physiological stimuli and directed to the heart and peripheral beds. In contrast, the changes in ventricular rate that occur with arrhythmias are not part of a co-ordinated autonomic response, but themselves initiate changes in cardiac function and arterial pressure which in turn evoke autonomic and local effects inappropriate for physiological needs. Figure 1 shows just how large and dramatic these changes can be, particularly in relation to the coronary circulation, where alternating bouts of tachy- and bradyarrhythmia elicit marked fluctuations in coronary blood flow and resistance. Such changes are of considerable interest in view of their potential influence on organ function in diseased circulations, e.g. in the heart and kidney. For this reason, we have examined the pattern of peripheral haemodynamics that occurs at different ventricular rates. The experiments were carried out in conscious dogs with experimentally induced heart block and with pacemaker leads sutured to the right ventricle. Ventricular rate was varied using a pacemaker unit.
- Subject
- arrhythmias; haemodynamic; cardiac output; blood flow velocity
- Identifier
- http://hdl.handle.net/1959.13/938981
- Identifier
- uon:12712
- Identifier
- ISSN:0065-2326
- Language
- eng
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