- Title
- Central nervous system 5-hydroxytryptamine and noradrenaline specificity of ear vascular and ventilation reflexes in thermoregulating rabbits
- Creator
- White, Saxon William; Traugott, F. M.; Quail, A. W.
- Relation
- Central Integration of Cardiopulmonary Autonomic Controls Symposium. Proceedings of the Central Integration of Cardiopulmonary Autonomic Controls Symposium [presented in Journal of the Autonomic Nervous System, Vol. 12, No. 2-3 (Callaghan, N.S.W. 25-27 August, 1983)
- Publisher Link
- http://dx.doi.org/10.1016/0165-1838(85)90056-6
- Publisher
- Elsevier
- Resource Type
- conference paper
- Date
- 1985
- Description
- Contrasting hypotheses of mammalian thermoregulation were tested in unanesthetized rabbits in relation to the role of the central nervous (CNS) monoamines 5-hydroxytryptamine (5-HT) and noradrenaline (NA) in regulating lung function and ear skin blood flow (Doppler flowmeter). Normal rabbits and rabbits with CNS depletion of 5-HT and NA (caused by the neurotoxins 5,7-dihydroxytryptamine and 6-hydroxydopamine) were studied in an airconditioned chamber at ambient temperatures of 12 °, 22 ° and 35°C. The results suggest that CNS 5-HT plays an excitatory role in the heat conservation mechanism of cold-induced ear skin vasoconstriction, and that this effect is inhibited by CNS NA to cause heat dissipation during heat stress. Both CNS 5-HT and NA appear to exert a mild inhibitory restraint on ventilation even during heat stress. The data support the theory that CNS 5-HT is concerned with heat conservation and CNS NA with heat loss mechanisms in the cutaneous circulation, and that both monoamines moderate heat loss through panting. CNS monoamine-dependent thermoregulation in the rabbit thus resembles the model postulated for the cat, dog and monkey rather than, as previously proposed, for the sheep and goat.
- Subject
- ear circulation; ventilation; CNS noradrenaline; CNS 5-hydroxtryptamine; temperature regulation; 5,7-dihydroxytryptamine
- Identifier
- http://hdl.handle.net/1959.13/938931
- Identifier
- uon:12701
- Identifier
- ISSN:0165-1838
- Language
- eng
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