- Title
- Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: a test-negative case control study
- Creator
- Cheng, Allen C.; Kotsimbos, Tom; Wood-Baker, Richard; Senanayake, Sanjaya N.; Brady, Stephen J.; Paterson, David L.; Wark, Peter A.; Upham, John W.; Korman, Tony M.; Dwyer, Dominic E.; Waterer, Grant W.; Kelly, Paul M.; Kelly, Heath A.; Irving, Louis B.; Bowler, Simon D.; Brown, Simon G. A.; Holmes, Mark; Jenkins, Christine R.; Thompson, Philip; Simpson, Graham
- Relation
- Vaccine Vol. 29, Issue 43, p. 7320-7325
- Publisher Link
- http://dx.doi.org/10.1016/j.vaccine.2011.07.087
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2011
- Description
- We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.
- Subject
- influenza complications; case control studies; influenza vaccines
- Identifier
- http://hdl.handle.net/1959.13/936912
- Identifier
- uon:12440
- Identifier
- ISSN:0264-410X
- Language
- eng
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