- Title
- Prevalence and risk factors of gastrointestinal disorders in patients with rheumatoid arthritis: results from a population-based survey in Olmsted County, Minnesota
- Creator
- Myasoedova, Elena; Talley, Nicholas J.; Manek, Nisha J.; Crowson, Cynthia S.
- Relation
- Gastroenterology Research and Practice
- Publisher Link
- http://dx.doi.org/10.1155/2011/745829
- Publisher
- Hindawi Publishing
- Resource Type
- journal article
- Date
- 2011
- Description
- Objectives: To compare the prevalence of gastrointestinal (GI) disorders in rheumatoid arthritis (RA) versus non-RA subjects and to describe determinants of GI disorders in RA. Methods: The bowel disease questionnaire was completed by RA and non-RA subjects. RA patients also completed the health assessment questionnaire (HAQ). Results: The study responders included 284 RA and 233 non-RA subjects. Abdominal pain/discomfort, postprandial fullness, nausea, and stool leakage were significantly more common in RA versus non-RA (odds ratios [OR] = 1.8; 1.9; 4.0; 8.2, resp.). The use of laxatives, proton pump inhibitors, NSAIDs, acetaminophen, and narcotics was more commonly reported in RA versus non-RA (OR = 2.0; 1.7; 3.0; 2.0; 1.9, resp.). Age < 60 and HAQ ≥ 1 were associated with dyspepsia, irritable bowel syndrome, gastroesophageal reflux disease, and GI symptom complex overlap in RA. Conclusion: Several upper and lower GI disorders were significantly more prevalent in RA versus non-RA subjects. Age <60 and physical function impairment (HAQ ≥ 1) were associated with GI disorders in RA.
- Subject
- rheumatoid arthritis; gastrointestinal disorders; irritable bowel syndrome; risk factors
- Identifier
- http://hdl.handle.net/1959.13/936697
- Identifier
- uon:12381
- Identifier
- ISSN:1687-6121
- Language
- eng
- Full Text
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