- Title
- Baroreflex control of coronary blood flow varies regionally in awake dogs
- Creator
- Quail, Anthony W.; Cottee, David B. F.; White, Saxon William; Proges, William L.; Hennessy, Edmund J.
- Relation
- Clinical and Experimental Pharmacology and Physiology Vol. 23, Issue 10-11, p. 866-873
- Publisher Link
- http://dx.doi.org/10.1111/j.1440-1681.1996.tb01135.x
- Publisher
- Wiley-Blackwell Publishing Asia
- Resource Type
- journal article
- Date
- 1996
- Description
- 1. Baroreflex responses to changes in aortic pressure were measured simulataneously in three main coronary regions of awake dogs. 2. Pulsed Doppler flow probes were mounted at prior surgery on the right, circumflex and anterior descending coronary arteries; the animals were placed in complete heart block and the left ventricle was placed. After 2-4 weeks recovery, baroreflexes were evoked by inflating a balloon catheter placed in the mid-thoracic aorta via the femoral arteriotomy. Flow and pressure data were collected at rest, and during acute (8 s) and steady-state (25 s) baroreflex challenge. 3. Changing ventricular rate alone caused a fall in aortic pressure at low rates; however, over the range 60 to 180 b.p.m., circumflex and anterior descending coronary flow and conductance changed directly with ventricular rate, but right coronary flow and conductance remained unchanged. 4. Acute aortic pressure elevation increased flow at 8 s in all beds at all rates. Conductance effects at 60 b.p.m. were negligible in all three beds, but rose at 100 and 180 b.p.m. in the right and circumflex beds. 5. Sustained aortic pressure elevation (25 s) caused flow to return towards control in all beds at all ventricular rates, but in the right coronary at 60 b.p.m. flow fell below control. Conductance at this time was unchanged at all rates in the anterior descending bed, fell modestly in the circumflex, and decreased to below resting in the right coronary bed. 6. Baroreflex control of coronary flow and conductance thus varies between territories, and within territories, depending on ventricular rate. The right coronary bed appears to be regulated by a bidirectional, baroreflex-linked mechanism, which is functionally opposite in action to that found in most vascular beds
- Subject
- baroreflex; conscious dog; coronary arteries; coronary blood flow; nebivolol; pulsed Doppler velocimeter
- Identifier
- http://hdl.handle.net/1959.13/936060
- Identifier
- uon:12201
- Identifier
- ISSN:0305-1870
- Rights
- Please contact Emeritus Professor Saxon White if you would like a copy of the published version of this paper. Email: Saxon.White@newcastle.edu.au
- Language
- eng
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